Differential Expression of the Zinc Finger Gene TCF17 in Testicular Tumors1
نویسندگان
چکیده
TCP 17, the human homologue of the rat zinc fìngergene Kidl, is highly expressed in neurons derived from the retinoic acid-treated human em bryonal carcinoma (EC) cell line, NTERA-2. This differentiation-related up-regulation of TCFÌ7 prompted us to investigate its expression during human spermatogenesis and in human testicular germ cell tumors con sidered to be precursors of EC. Expression of TCP 17 increases as spermatogonia differentiate into spermatocytes, indicating that this gene is devclopmentally regulated during spermatogenesis. TCF17 mRNA levels are high in carcinoma in situ and in seminoma, a tumor derived from carcinoma in situ but still of low-grade malignancy. However, TCF17 expression is decreased in highly malignant EC. The differential regula tion of TCP 17 during neoplastic germ cell differentiation may be of predictive value in germ cell tumor diagnosis.
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